Concepedia

Pharmacophore-based design and discovery of (−)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis

Qiong Xie, Zhaoxi Zheng, Wei Fu, Zheng Xia, Wei Li, Jian Sun, Wei Zheng, Weiwei Zhang, Wei Sheng, Qihong Zhang,

Journal of Enzyme Inhibition and Medicinal Chemistry · 2017 · 16 citations · 40 references

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Abstract

cells at 50 µM. The dual actions of 43 on cholinergic and amyloidogenic pathways indicated potential uses as symptomatic and disease-modifying agents.

References

40

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Inge Grundke‐Iqbal, Khurshid Iqbal, Y C Tung et al. · Proceedings of the National Academy of Sciences · 1986 · 3.6K citations · Full text

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ADVANCES IN BEHAVIORAL BIOLOGY

Jan Bureš, Irwin J. Kopin, Bruce S. McEwen et al. · 1972 · 270 citations

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Novel Dual Inhibitors of AChE and MAO Derived from Hydroxy Aminoindan and Phenethylamine as Potential Treatment for Alzheimer's Disease

Jeffrey Sterling, Yaacov Herzig, Tamar Goren et al. · Journal of Medicinal Chemistry · 2002 · 251 citations · Full text

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Modified Ellman procedure for assay of cholinesterases in crude enzymatic preparations

Victoria Gorun, Ioan Proinov, Valeria Băltescu et al. · Analytical Biochemistry · 1978 · 242 citations

, , +13