Dynamic cyclic compression modulates the chondrogenic phenotype in human chondrocytes from late stage osteoarthritis

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

R. Clark Billinghurst, Leif Dahlberg, Mirela Ionescu et al. · Journal of Clinical Investigation · 1997 · 975 citations · Full text

Medicine, Orthopaedic Surgery, Pathology +14

SOX9 Binds DNA, Activates Transcription, and Coexpresses with Type II Collagen during Chondrogenesis in the Mouse

Ling-Jim Ng, Susan C. Wheatley, George E.O. Muscat et al. · Developmental Biology · 1997 · 674 citations

Life Sciences, Genetics, Molecular Biology +8

Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix

Michael D. Buschmann, Yehezkiel A. Gluzband, Alan J. Grodzinsky et al. · Journal of Orthopaedic Research® · 1992 · 531 citations

Medicine, Bioengineering, Cell Biology +17

Role of interleukin‐1 and tumor necrosis factor α in matrix degradation of human osteoarthritic cartilage

Masahiko Kobayashi, Ginette R. Squires, Aisha Mousa et al. · Arthritis & Rheumatism · 2005 · 505 citations

Medicine, Immunology, Orthopaedic Surgery +17

Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology

Thomas Aigner, Alexander Zien, Angelika Gehrsitz et al. · Arthritis & Rheumatism · 2001 · 476 citations

Life Sciences, Cell Biology, Molecular Biology +17