Enzymatic reactive crystallization for improving ampicillin synthesis

Effect of pH in the synthesis of ampicillin by penicillin acylase

Sonia Ospina, Eduardo Bárzana, Octavio T. Ramı́rez et al. · Enzyme and Microbial Technology · 1996 · 88 citations

Penicillin Acylase, Medicinal Chemistry, Biosynthesis +7

Thermodynamically controlled synthesis of β-lactam antibiotics. Equilibrium concentrations and side-chain properties

Vincent Nierstrasz, P. J. Kroon, Rouke Bosma et al. · Enzyme and Microbial Technology · 1999 · 66 citations · Full text

β-Lactam Antibiotics, Side-chain Properties, Medicine +7

Quantitative characterization of the nucleophile reactivity in penicillin acylase-catalyzed acyl transfer reactions

Maxim I. Youshko, Ghermes G. Chilov, Tatyana A. Shcherbakova et al. · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 2002 · 61 citations

Nucleophile Reactivity, Biochemistry, Natural Sciences +6

Kinetics of enzyme acylation and deacylation in the penicillin acylase‐catalyzed synthesis of β‐lactam antibiotics

Wynand Alkema, Erik de Vries, René Floris et al. · European Journal of Biochemistry · 2003 · 47 citations · Full text

Biosynthesis, Engineering, Biochemistry +14

Predicting the Aqueous Solubility of Pharmaceutical Cocrystals As a Function of pH and Temperature

Linda Lange, Kristin Lehmkemper, Gabriele Sadowski · Crystal Growth & Design · 2016 · 41 citations

Engineering, Supercritical Fluid Chromatography, Chemistry +18