Quality and stability of extemporaneous pyridoxal phosphate preparations used in the treatment of paediatric epilepsy

Abstract

Pyridoxal 5'-phosphate tablets from Solgar^® were found to be the most reliable product for the preparation of extemporaneous PLP liquids. This work highlighted the difference between the marketed PLP dietary supplements quality and the importance of proper storage of aqueous PLP. There is a need to develop pharmaceutical forms of PLP that ensure dose accuracy and avoid potentially unsafe impurities with the aim of enhancing safety and compliance.