<scp>CADASIL</scp>: Ultrastructural insights into the morphology of granular osmiophilic material

Abstract

This study demonstrates that GOM deposits may have a nonuniform morphology and describes in detail an electron-lucent halo surrounding several of them. It is conceivable that the halo is the morphological evidence and possibly the cause of an aberrant NOTCH3 processing, already suspected to be involved in CADASIL.