Concepedia

PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells

Cécile Naudin, Aurore Hattabi, Fabio Michelet, Ayda Miri-Nezhad, Aissa Benyoucef, Françoise Pflumio, François Guillonneau, Serge Fichelson, Isabelle Vigon, Isabelle Dusanter‐Fourt,

Blood · 2017 · 122 citations · 46 references

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Abstract

cell cycle inhibitors. Enforced FOXP1 expression reverses shPUM antiproliferative and proapoptotic activities. Altogether, our results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1/2 and FOXP1 in regulating normal HSPC and leukemic cell growth.

References

46

FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

Zuzana Tóthová, Ramya Kollipara, Brian J.P. Huntly et al. · Cell · 2007 · 1.5K citations · Full text

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Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

Vı́ctor Quesada, Laura Peña Conde, Neus Villamor et al. · Nature Genetics · 2011 · 996 citations · Full text

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Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins

Sung‐Yul Lee, Florian Kopp, Tsung-Cheng Chang et al. · Cell · 2015 · 954 citations · Full text

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Foxo3a is essential for maintenance of the hematopoietic stem cell pool

Kana Miyamoto · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · 2009 · 846 citations · Full text

, , +8

Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution

Colleen Delaney, Shelly Heimfeld, Carolyn Brashem‐Stein et al. · Nature Medicine · 2010 · 768 citations · Full text

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