Copper‐Catalyzed Remote C‐H Sulfonylation of 8‐Aminoquinoline Amides with Arylsulfonyl Hydrazides

Abstract

Abstract An efficient copper‐catalyzed remote C‐5 sulfonylation of 8‐aminoquinoline amides using stable and readily available arylsulfonyl hydrazides has been developed. In the presence of 10 mol‐% Cu(OAc) 2 as a catalyst and Ag 2 CO 3 as an oxidant, a wide range of 8‐aminoquinoline amides underwent sulfonylation with arylsulfonyl hydrazides to generate structurally diverse aryl sulfones in moderate to good yields.