Blood · 2017 · 117 citations · 43 references
Life SciencesHematologyImmunologyImmunoregulationInflammationInnate ImmunityAcute InflammationAcute Lung InjuryDendritic Cell BiologyInflammatory SignalingRegulatory T CellsT Cell BiologyAcute Lung InflammationAcute Lung Injury PathophysiologyInterleukin-10 Mediated ImmunosuppressionInterleukin-10 Production By Regulatory T CellsT Cell-mediated InflammationT Cell-mediated ProtectionT-cell Mediated Inflammation
dendritic cells (DCs) to be critical effectors that protect against TRALI. Treg or DC depletion in vivo resulted in aggravated antibody-mediated acute lung injury within 90 minutes with 60% mortality upon DC depletion. In addition, resistance to antibody-mediated TRALI was associated with increased interleukin-10 (IL-10) levels, and IL-10 levels were found to be decreased in mice suffering from TRALI. Importantly, IL-10 injection completely prevented and rescued the development of TRALI in mice and may prove to be a promising new therapeutic approach for alleviating lung injury in this serious complication of transfusion.
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Gustavo Matute‐Bello, Gregory P. Downey, Bethany B. Moore et al. · American Journal of Respiratory Cell and Molecular Biology · 2011 · 2K citations · Full text
Transfusion-related acute lung injury: incidence and risk factors
Pearl Toy, Ognjen Gajic, Peter Bacchetti et al. · Blood · 2011 · 564 citations · Full text