Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-α production in vivo

Rukhsana Aslam, Edwin R. Speck, Michael D. Kim, +7

Blood

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell–mediated responses that are differentially sensitive to therapy

Leola Chow, Rukhsana Aslam, Edwin R. Speck, +10

Blood

T granules in human platelets function in TLR9 organization and signaling

Jonathan N. Thon, Christopher G. Peters, Kellie R. Machlus, +9

The Journal of Cell Biology

Innate Immune SystemImmunologyBlood CellImmunologic MechanismInnate Immunity +20

Platelet-bound lipopolysaccharide enhances Fc receptor–mediated phagocytosis of IgG-opsonized platelets

John W. Semple, Rukhsana Aslam, Michael Kim, +2

Blood

Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets

Anne Zufferey, Edwin R. Speck, Kellie R. Machlus, +8

Blood Advances

T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10

Rick Kapur, Michael D. Kim, Rukhsana Aslam, +16

Blood

Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

Rukhsana Aslam, Yu Hu, Simon Gebremeskel, +7

Blood

Transfusion‐related immunomodulation by platelets is dependent on their expression of MHC Class I molecules and is independent of white cells

Rukhsana Aslam, Edwin R. Speck, Michael Kim, +2

Transfusion

Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury

Yoke Lin Fung, Michael Kim, Arata Tabuchi, +6

Blood

Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP)

Rick Kapur, Rukhsana Aslam, Edwin R. Speck, +2

Platelets

ImmunologyMurine Tpo-raImmunotherapyPlatelet CountsThrombosis +15