Dapagliflozin‐lowered blood glucose reduces respiratory <scp><i>Pseudomonas aeruginosa</i></scp> infection in diabetic mice

Abstract

Pharmacological lowering of blood glucose with dapagliflozin effectively reduced P. aeruginosa infection in the lungs of diabetic mice and had no adverse pulmonary effects in the rat. Dapagliflozin has potential to reduce the use, or augment the effect, of antimicrobials in the prevention or treatment of pulmonary infection.