Solvent-, and Catalyst-free Acylation of Anilines with Meldrum's Acids: ANeat Access to Anilides

Abstract

An efficient and neat procedure for N-acylation of anilines has been developed using 5-(un)substituted Meldrum's acids as acyl surrogates under neutral conditions in excellent yields. This protocol features a solvent-free and catalyst-free acylation process, and enables facile access to a vast array of structurally versatile sec- and tert-anilides.