Concepedia

Safety, efficacy and pharmacokinetics of rVIII‐SingleChain in children with severe hemophilia A: results of a multicenter clinical trial

Oleksandra Stasyshyn, Claudia Djambas Khayat, Genadi Iosava, J. Ong, F. Abdul Karim, Kathelijn Fischer, Alex Veldman, Nicole Blackman, Katie St. Ledger, Ingrid Pabinger

Journal of Thrombosis and Haemostasis · 2017 · 37 citations · 15 references

Open access

Concepts

MedicineHematologyPharmacokineticsClinical PharmacologyHemostasisPediatric HematologyBleeding DisordersCoagulation AbnormalitiesCoagulation Factor DeficienciesHemostatic AgentsVon Willebrand DiseaseBleedingBleeding Phenotype AssessmentFactor Viii Binding DeficiencyFactor Viii PhysiologyHemostatic EfficacyOn-demand TherapyProduct Safety ProfileRecombinant Activated Factor Vii

References

15

World Medical Association Declaration of Helsinki

JAMA · 2013 · 29.4K citations

Health Professions, Health Sciences, Clinical Medicine +2

WORLD MEDICAL ASSOCIATION DECLARATION OF HELSINKI: Ethical Principles for Medical Research Involving Human Subjects

Journal of obstetrics and gynaecology research · 2001 · 3.5K citations · Full text

Law, Health Policy, Clinical Research Regulation +13

Guidelines for the management of hemophilia

Alok Srivastava, A. Brewer, Evelien P. Mauser‐Bunschoten et al. · Haemophilia · 2012 · 1.9K citations · Full text

Medicine, Hematology, Internal Medicine +16

Recombinant factor VIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A

Guy Young, Johnny Mahlangu, Roshni Kulkarni et al. · Journal of Thrombosis and Haemostasis · 2015 · 169 citations · Full text

Medicine, Hematology, Pharmacotherapy +17

Plasma and albumin‐free recombinant factor VIII: pharmacokinetics, efficacy and safety in previously treated pediatric patients

Victor S. Blanchette, Amy D. Shapiro, Ri Liesner et al. · Journal of Thrombosis and Haemostasis · 2008 · 142 citations

Pharmacy, Hematology, Pharmacokinetics +13