Comparative Effectiveness of Vancomycin and Metronidazole for the Prevention of Recurrence and Death in Patients With <i>Clostridium difficile</i> Infection

Abstract

Recurrence rates were similar among patients treated with vancomycin and metronidazole. However, the risk of 30-day mortality was significantly reduced among patients who received vancomycin. Our findings may further justify the use of vancomycin as initial therapy for severe CDI.