Concepedia

Effects of linagliptin on human immortalized podocytes: a cellular system to study dipeptidyl‐peptidase 4 inhibition

Gianluca Miglio, G. Vitarelli, Thomas Klein, Elisa Benetti

British Journal of Pharmacology · 2017 · 11 citations · 52 references

DOIFull text

Open access

Abstract

Our cultures of human glomerular cells represent a reliable system for investigating the actions of gliptins. Moreover, DPP4 contributes to the regulation of podocyte behaviour. Inhibition of DPP4 in podocytes could underlie the effects of linagliptin on glomerular cells.

References

52

THE TOXICITY OF POISONS APPLIED JOINTLY1

C. I. Bliss · Annals of Applied Biology · 1939 · 2.4K citations

, , +15

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Christopher Southan, Joanna L Sharman, Helen E. Benson et al. · Nucleic Acids Research · 2015 · 1K citations · Full text

, , +22

The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors

S P H Alexander, Anthony P. Davenport, Eamonn Kelly et al. · British Journal of Pharmacology · 2015 · 844 citations · Full text

(2<i>R</i>)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-<i>a</i>]pyrazin- 7(8<i>H</i>)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine:  A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Dooseop Kim, Liping Wang, Maria Beconi et al. · Journal of Medicinal Chemistry · 2004 · 808 citations · Full text

GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

Charles Pyke, R. Scott Heller, Rikke Kaae Kirk et al. · Endocrinology · 2014 · 802 citations · Full text

, , +22