Evidence for Intestinal Secretion as an Additional Clearance Pathway of Talinolol Enantiomers: Concentration- and Dose-dependent Absorption in Vitro and in Vivo

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Proceedings of the National Academy of Sciences · 1987 · 2.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) Cells

Per Artursson · Journal of Pharmaceutical Sciences · 1990 · 836 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators

Janice Hunter, Mark A. Jepson, T Tsuruo et al. · Journal of Biological Chemistry · 1993 · 367 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Drug Absorption Limited by P-Glycoprotein-Mediated Secretory Drug Transport in Human Intestinal Epithelial Caco-2 Cell Layers

Janice Hunter, Barry H. Hirst, Nicholas L. Simmons · Pharmaceutical Research · 1993 · 221 citations

Pharmacy, Pharmaceutics, Pharmacology +14

The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine; an explanation for the double peak phenomenon

Rebecca L. Oberle, Gordon L. Amidon · Journal of Pharmacokinetics and Biopharmaceutics · 1987 · 208 citations

Pharmacy, Pharmacokinetics, Pharmacology +17