Concepedia

The miR-383-LDHA axis regulates cell proliferation, invasion and glycolysis in hepatocellular cancer.

Zhixiong Fang, Langqiu He, Hui Jia, Qiusheng Huang, Dan Chen, Zhiwei Zhang

PubMed · 2017 · 41 citations · 16 references

DOIFull text

Open access

Abstract

Our study proved that miR-383 is down-regulated in HCC and acts as a tumor suppressor through targeting LDHA. Targeting the miR-383-LDHA axis might be a promising strategy in HCC treatment.

References

16

Global cancer statistics, 2012

Lindsey A. Torre, Freddie Bray, Rebecca L. Siegel et al. · CA A Cancer Journal for Clinicians · 2015 · 27.2K citations · Full text

FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA Expression

Jiujie Cui, Min Shi, Dacheng Xie et al. · Clinical Cancer Research · 2014 · 239 citations · Full text

Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells

Yefei Rong, Wenchuan Wu, Xiaoling Ni et al. · Tumor Biology · 2013 · 193 citations

Lactate Dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma

Hala Girgis, Olena Masui, Nicole M. White et al. · Molecular Cancer · 2014 · 192 citations · Full text

Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer

Jian Wang, Hui Wang, Aifen Liu et al. · Oncotarget · 2015 · 148 citations · Full text

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