A transcriptomic study suggesting human iPSC-derived hepatocytes potentially offer a better in vitro model of hepatotoxicity than most hepatoma cell lines

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

Kazutoshi Takahashi, Shinya Yamanaka · Cell · 2006 · 26.5K citations · Full text

Life Sciences, Cell Biology, Developmental Biology +16

Hierarchical Grouping to Optimize an Objective Function

Joe H. Ward · Journal of the American Statistical Association · 1963 · 19.2K citations

Natural Sciences, Computer Science, Mathematics +15

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

Rafael A. Irizarry · Biostatistics · 2003 · 10.7K citations · Full text

Life Sciences, Biology, Genetics +14

What is principal component analysis?

Markus Ringnér · Nature Biotechnology · 2008 · 2.5K citations

Computing, Computer Science, Feature Engineering +9

Growth of human hepatoma cells lines with differentiated functions in chemically defined medium.

Hidekazu Nakabayashi, Kazuhisa Taketa, Keiko Miyano et al. · PubMed · 1982 · 1.4K citations

Medicine, Cell Biology, Oncology +10