PubMed · 2017 · 70 citations · 34 references
MedicineCancer BiologyMolecular BiologyMetastasisMolecular OncologyTumor ProgressionCancer ProgressionMicrorna BiologyMicrorna-mediated RegulationNoncoding Rna BiologyNoncoding Rna In CancerOncogenic Signaling PathwaysCell Cycle Arrest MechanismsCompetitive Endogenous Rna RegulationMelanoma ProgressionMicrorna Function In CancerMicrorna In CancerMicrorna-mediated OncogenesisNoncoding Rna In MetastasisPi3k-akt Signaling Pathway
functional experiments further confirmed the pro-growth and pro-metastasis roles of MHENCR. Collectively, our findings revealed that MHENCR functions as an oncogene in melanoma via activating miR-425/489-mediated PI3K-Akt pathway, and may be a therapeutic target for melanoma.
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Global cancer statistics, 2012
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