Concepedia

MTCH2 is a conserved regulator of lipid homeostasis

Veerle Rottiers, Adam B. Francisco, Michael Platov, Yehudit Zaltsman, Antonella Ruggiero, Siu Sylvia Lee, Atan Gross, Sergiy Libert

Obesity · 2017 · 39 citations · 36 references

DOIFull text

Open access

Abstract

MTCH2 is a conserved regulator of lipid homeostasis. MTCH2 was found to be both required and sufficient for lipid homeostasis shifts, suggesting that pharmacological inhibition of MTCH2 could be therapeutic for treatment of obesity and related disorders. MTCH2 could influence lipid homeostasis through inhibition of ESR1 activity.

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