Mechanism of inhibition of botulinum neurotoxin type A light chain by two quinolinol compounds

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Appropriate calibration curve fitting in ligand binding assays

John W. A. Findlay, Robert F. Dillard · The AAPS Journal · 2007 · 371 citations · Full text

Medicine, Chemistry, Analytical Chemistry +11

IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding

Regina Z. Cer, Uma Mudunuri, R. Scott Stephens et al. · Nucleic Acids Research · 2009 · 367 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Substrate recognition strategy for botulinum neurotoxin serotype A

Mark A. Breidenbach, Axel T. Brünger · Nature · 2004 · 330 citations

Life Sciences, Neurology, Neuroscience +11

Botulinum neurotoxins are zinc proteins.

Giampietro Schiavo, Ornella Rossetto, Annalisa Santucci et al. · Journal of Biological Chemistry · 1992 · 260 citations · Full text

Life Sciences, Biochemistry, Enzymology +11