TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis

TDP-43 is a key player in the clinical features associated with Alzheimer’s disease

Keith A. Josephs, Jennifer L. Whitwell, Stephen D. Weigand et al. · Acta Neuropathologica · 2014 · 465 citations · Full text

Neurodegenerative Diseases, Key Player, Molecular Neuroscience +14

Efficient construction of a large nonimmune phage antibody library: The production of high-affinity human single-chain antibodies to protein antigens

Michael Sheets, Peter Amersdorfer, Ricarda Finnern et al. · Proceedings of the National Academy of Sciences · 1998 · 438 citations · Full text

Colocalization of Transactivation-Responsive DNA-Binding Protein 43 and Huntingtin in Inclusions of Huntington Disease

Claudia Schwab, Tetsuaki Arai, Masato Hasegawa et al. · Journal of Neuropathology & Experimental Neurology · 2008 · 259 citations · Full text

Genetics, Genomic Mechanism, Molecular Biology +16

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)

Kathryn Volkening, Cheryl Leystra‐Lantz, Wenchang Yang et al. · Brain Research · 2009 · 206 citations

Amyotrophic Lateral Sclerosis, Biochemistry, Natural Sciences +5

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients

Yu-Sheng Fang, Kuen‐Jer Tsai, Yu-Jen Chang et al. · Nature Communications · 2014 · 198 citations · Full text

Amyloid Oligomers, Neurodegenerative Diseases, Alzheimer's Disease +10