Nalfurafine is a G-protein biased agonist having significantly greater bias at the human than rodent form of the kappa opioid receptor

Opioid Epidemic in the United States

Laxmaiah Manchikanti · Pain Physician · 2012 · 1.2K citations · Full text

Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses.

Jay P. McLaughlin, Monica Marton-Popovici, Charles Chavkin · PubMed · 2003 · 480 citations · Full text

Opioid Epidemic, Stress-induced Behavioral Responses, Pain Medicine +22

κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses

Jay P. McLaughlin, Monica Marton-Popovici, Charles Chavkin · Journal of Neuroscience · 2003 · 428 citations · Full text

Opioid Epidemic, Pain Medicine, Molecular Pain +20

Retention of heroin and morphine–6β–glucuronide analgesia in a new line of mice lacking exon 1 of MOR–1

Alwin G. Schuller, Michael A. King, Jiwen Zhang et al. · Nature Neuroscience · 1999 · 305 citations

Pain Medicine, Molecular Pain, Experimental Pharmacology +17

Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking

Benjamin B. Land, Michael R. Bruchas, Selena S. Schattauer et al. · Proceedings of the National Academy of Sciences · 2009 · 300 citations · Full text

Pain Medicine, Psychopharmacology, Molecular Pain +22