The significance of glypican‐3 expression profiling in the tumor cellular origin theoretical system for hepatocellular carcinoma progression

Abstract

Glypican-3 is correlated with the clinical malignant behavior of HCC. Moreover, GPC3 phenotype changes from positive to negative during tumor cells differentiation. Meanwhile, GPC3 plays a significant role in tumor cellular origin theoretical system, which can better reflect the malignant essence of tumors.