Concepedia

Improved and General Manganese‐Catalyzed N‐Methylation of Aromatic Amines Using Methanol

Jacob Neumann, Saravanakumar Elangovan, Anke Spannenberg, Kathrin Junge, Matthias Beller

Chemistry - A European Journal · 2017 · 212 citations · 45 references

DOI

Abstract

A novel lutidine-based manganese PNP-pincer complex has been synthesized for the selective N-methylation of aromatic amines with methanol. Using borrowing hydrogen methodology, a selection of differently functionalized aniline derivatives is selectively methylated in good yields.

References

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The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

Stephen D. Roughley, Allan M. Jordan · Journal of Medicinal Chemistry · 2011 · 2.6K citations

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Efficient and selective N-alkylation of amines with alcohols catalysed by manganese pincer complexes

Saravanakumar Elangovan, Jacob Neumann, Jean‐Baptiste Sortais et al. · Nature Communications · 2016 · 626 citations · Full text

Selective Catalytic Hydrogenations of Nitriles, Ketones, and Aldehydes by Well-Defined Manganese Pincer Complexes

Saravanakumar Elangovan, Christoph Topf, Steffen Fischer et al. · Journal of the American Chemical Society · 2016 · 585 citations

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Manganese-Catalyzed Environmentally Benign Dehydrogenative Coupling of Alcohols and Amines to Form Aldimines and H<sub>2</sub>: A Catalytic and Mechanistic Study

Arup Mukherjee, Alexander Nerush, Gregory Leitus et al. · Journal of the American Chemical Society · 2016 · 470 citations

, , +10

Big Data from Pharmaceutical Patents: A Computational Analysis of Medicinal Chemists’ Bread and Butter

Nadine Schneider, Daniel M. Lowe, Roger A. Sayle et al. · Journal of Medicinal Chemistry · 2016 · 431 citations