Concepedia

A GSH-activatable ruthenium(<scp>ii</scp>)-azo photosensitizer for two-photon photodynamic therapy

Leli Zeng, Shi Kuang, Guanying Li, Chengzhi Jin, Liang‐Nian Ji, Hui Chao

Chemical Communications · 2017 · 109 citations · 37 references

DOI

Concepts

Abstract

A glutathione (GSH)-activatable ruthenium(ii)-azo photosensitizer was prepared. The complex had low toxicity towards cells under dark conditions. It exhibited excellent phototoxicity under two-photon excitation (810 nm) and thus was developed as a two-photon photodynamic anticancer agent for cancer therapy.

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