Ultrasonic and Grinding Aptitudes of One‐Pot Synthesis of 5‐(4‐Chlorophenyl)‐7‐(3,4‐Dimethyl Phenyl)‐2‐oxo‐2H‐Pyrano[2,3‐b]Pyridine Derivatives as Antibacterial Agents

Abstract

A simple facile “one‐pot” synthesis of 5‐(4‐chlorophenyl)‐7‐(3,4‐dimethyl phenyl)‐2‐oxo‐2H‐pyrano[2,3‐b]pyridine derivatives via three‐component reaction of chalcone, ethyl‐2‐substituted acetate, and ammonium acetate under ultrasonic irradiation and grinding tools. The newly synthesized compounds were evaluated for their antibacterial activity against ATCC 25923, ATCC 10987, ATCC 274, and SM514. All the synthesized compounds have been characterized on the basis of their elemental analyses and spectral data.