Recent Advances in Multicomponent Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazoles

Abstract

Abstract 1,4,5‐Trisubstituted 1,2,3‐triazoles have been regarded as highly significant nitrogen‐containing heterocycles due to their broad spectrum of biological activities and other prominent properties. Well‐established pioneering examples indicate that multicomponent reactions (MCRs) are a straightforward and powerful tool for the construction of various functionalized heterocyclic molecules, especially fully‐decorated 1,2,3‐triazoles. The recent progress regarding synthetic approaches towards differently substituted types of 1,2,3‐triazoles via MCRs and the relevant mechanistic investigations is summarized in this review. magnified image