Journal of Intercultural Ethnopharmacology · 2017 · 16 citations · 30 references
MedicineBiochemistryPharmacologyBiochemical PharmacologyEnzymologyNeuropharmacologyCholinergic NeurochemistryCholinergic PharmacologyEnzyme InhibitionNeurodegenerative Disease PharmacologyNeurodegenerative Disease PharmacotherapyNeuroprotectionAcetylcholinesterase FunctionAcetylcholinesterase InhibitorsAche InhibitionAqueous Plant ExtractsCholine Acetyltransferase ActivityCrude Extract PreparationPharmacological Treatment Of DementiaThrombolytic Enzymes
BACKGROUND: (L.) has widely known for its medicinal values. Our aim is to investigate the cholinesterase inhibitory activities as well as thrombolytic activities of the bark and seeds crude methanolic extracts (CMEs) in the treatment of AD and clotting disorder. MATERIALS AND METHODS: The crude methanol extract was prepared by cold extraction method and was assessed for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities by the Ellman's method. For thrombolytic activity clot lysis method was applied. RESULTS: thrombolytic activity of bark was 30.17% and of seed it was 22.53%. CONCLUSION: The results revealed that the CME of bark and seed both have moderate cholinesterases inhibitory activities as well as thrombolytic activities, worth of further investigations to identify the promising molecule(s) potentially useful in the treatment of AD as well as in clotting disorders.
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A new and rapid colorimetric determination of acetylcholinesterase activity
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