Surface engineering tumor cells with adjuvant-loaded particles for use as cancer vaccines

An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

Manfred B. Lutz, Nicole A. Kukutsch, Alexandra Ogilvie et al. · Journal of Immunological Methods · 1999 · 3K citations

Life Sciences, Cell Biology, Immunology +11

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

Glen Dranoff, Elizabeth M. Jaffee, A Lazenby et al. · Proceedings of the National Academy of Sciences · 1993 · 2.8K citations

Medicine, Immunology, Oncology +17

Therapeutic cell engineering with surface-conjugated synthetic nanoparticles

Matthias T. Stephan, James J. Moon, Soong Ho Um et al. · Nature Medicine · 2010 · 738 citations · Full text

Natural Sciences, Bioengineering, Biomedical Engineering +14

Evaluation of Ipilimumab in Combination With Allogeneic Pancreatic Tumor Cells Transfected With a GM-CSF Gene in Previously Treated Pancreatic Cancer

Dung T. Le, Eric R. Lutz, Jennifer N. Uram et al. · Journal of Immunotherapy · 2013 · 554 citations

Medicine, Oncology, Pharmacology +17

Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial

Alfons JM van den Eertwegh, Jurjen Versluis, H. Pieter van den Berg et al. · The Lancet Oncology · 2012 · 357 citations

Medicine, Immunology, Oncology +16