662. Mesenchymal and Induced Pluripotent Stem Cells: General Insights and Clinical Perspectives

Abstract

Mesenchymal stem cells (MSC) have awakened a great deal of interest in regenerative medicine due to their plasticity, immunomodulatory and anti-inflammatory properties. They are easy in yield and can be acquired through non-invasive methods from adult tissues. Besides, are non-tumorigenic and are extensively studied. In the other hand, induced pluripotent stem (iPS) cells can be derived directly from adult cells through gene reprogramming. The new iPS technology avoids the embryo destruction or manipulation to generate pluripotent cells, therefore, are exempt of ethical implication surrounding embryonic stem cell use. The pre-differentiation of iPS cells can assure the safety of future approaches. Both MSC and iPS cells can be used to autologous cell transplantations without the risk of immune rejection and represent a great opportunity to future therapies. In this we discussed the therapeutic perspectives using mesenchymal and induced pluripotent stem cells and used the rabbit mouse of fat tissue stem cell and use it for IPs production. Perpectives and negatives highlights of this protocols will open venue for stem cell labs to produce safe different cell types using the rabbit model.