World Journal of Nephrology · 2016 · 13 citations · 13 references
MedicineClinical SciencesNephrologyInflammationRenal PathophysiologyChronic Kidney DiseaseInflammatory SignalingRenal DiseaseRenal InflammationRenal Vascular DiseaseSystemic Inflammatory ResponseCalcificationCkd ProgressionFgf23-klotho AxisFibroblast Growth Factor 21 SignalingFibroblast Growth Factor 23 DysregulationRenal Vascular CalcificationSystemic Inflammation Markers
Systemic inflammation is a recognized feature in chronic kidney disease (CKD). The role of systemic inflammation in the pathogenesis of vascular calcification was recently settled. FGF23 was recently accused as a direct stimulus of systemic inflammation. This finding explains the strong association of FGF23 to vascular calcification and increased mortality among CKD.
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