Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice

Intensive Insulin Therapy in Critically Ill Patients

Greet Van den Berghe, Pieter Wouters, Frank Weekers et al. · New England Journal of Medicine · 2001 · 10K citations · Full text

Medicine, Internal Medicine, Critical Care Medicine +10

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Darren A.E. Cross, Dario R. Alessi, Philip Cohen et al. · Nature · 1995 · 5.2K citations

Life Sciences, Biochemistry, Molecular Biology +12

Long-Term Cognitive Impairment after Critical Illness

Pratik P. Pandharipande, Timothy D. Girard, J.C. Jackson et al. · New England Journal of Medicine · 2013 · 2.8K citations · Full text

Medicine, Neurology, Neuroscience +13

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

Theodore J. Iwashyna, E. Wesley Ely, Dylan M. Smith et al. · JAMA · 2010 · 2.6K citations

Medicine, Neurology, Psychiatry +16

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Konrad Talbot, Hoau-Yan Wang, Hala Kazi et al. · Journal of Clinical Investigation · 2012 · 1.8K citations · Full text

Medicine, Neurology, Neuroscience +17