Replication of GWAS loci revealed the moderate effect of <i>TNRC6B</i> locus on susceptibility of Saudi women to develop uterine leiomyomas

Abstract

The rs12484776 significantly contributes to UL risk among Saudi women, both in single and also in synergistic cooperation with rs2280543, rs7913069, and rs1056836 markers. Our results have yielded mixed findings in replicating European- and Japanese-specific UL genetic susceptibility loci among a geographically and culturally distinct population of the Saudi Arabian Peninsula.