The Integrated Use of Alternative Approaches for Predicting Toxic Hazard

Abstract

Environmental Safety Laboratory, Unilever Research, Colworth House, Sharnbrook,Bedford MK44 1LQ, UK; Unidad de Hepatologia Experimental, Hospital Universitario La Fe, Avda de Campanar 21, 46009 Valencia, Spain; FRAME, Russell & Burch House, 96-98 North Sherwood Street, Nottingham NG1 4EE, UK; School of Pharmacy, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK; ECVAM, JRC Environment Institute, 21020 Ispra (Va), Italy; Bundesinstitut fur gesundheitlichen Verbraucherschutz und Veterinarmedizin (BgVV), Thielallee 88-92,14195 Berlin, Germany; Istitutodi R icercasulla Senescenza, Sigma-Tau, Via Pontina, km 30.400, 00040 Pomezia, Italy; Sanofi Research Division, Alnwick Research Centre, Alnwick, NorthumberlandNE66 2 JH, UK;ChemQuest, Cheyney House, 19-21 Cheyney Street, Steeple Morden, Herts. SG8 OLP, UK; ZENECA Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SKI 0 4TJ, UK; TNO Nutrition and Food Research Institute, Division of Toxicology, P.O. Box 360, 3700 AJ Zeist, The Netherlands; Research Institute of Toxicology (RITOX), Utrecht University, P.O. Box 80.176, Yalelaan 2, 3508 TD Utrecht, The Netherlands; SIAT, Missionsstrasse 60, 4055 Basel, Switzerland