Concepedia

A novel mechanism regulating human platelet activation by MMP-2–mediated PAR1 biased signaling

Manuela Sebastiano, Stefania Momi, Emanuela Falcinelli, Loredana Bury, Marc Hoylaerts, Paolo Gresele

Blood · 2016 · 85 citations · 54 references

DOIFull text

Open access

Concepts

Abstract

Key Points Active MMP-2 enhances platelet activation by cleaving PAR1 at an extracellular site different from the thrombin cleavage site. The novel PAR1-tethered ligand exposed by MMP-2 selectively stimulates PAR1-dependent Gq and G12/13 pathway activation.

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