Shikonin inhibits TNF-α production through suppressing PKC-NF-κB-dependent decrease of IL-10 in rheumatoid arthritis-like cell model

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

Tilman Schneider‐Poetsch, Jianhua Ju, Daniel E. Eyler et al. · Nature Chemical Biology · 2010 · 1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

Taiji Matsusaka, Kazuo Fujikawa, Yukihiro Nishio et al. · Proceedings of the National Academy of Sciences · 1993 · 963 citations

Life Sciences, Immunology, Molecular Biology +16

Immunoregulatory role of interleukin 10 in rheumatoid arthritis.

Peter D. Katsikis, Cong‐Qiu Chu, Fionula M. Brennan et al. · The Journal of Experimental Medicine · 1994 · 532 citations · Full text

Medicine, Immunology, Pathobiology +13

A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses.

Amy Chernoff, Eric V. Granowitz, Leland Shapiro et al. · The Journal of Immunology · 1995 · 421 citations

Life Sciences, Immunology, Pharmacotherapy +15

Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.

Isabelle P. Oswald, Thomas A. Wynn, Alan Sher et al. · Proceedings of the National Academy of Sciences · 1992 · 350 citations

Veterinary Medicine, Immunology, Infectious Diseases +17