Immune reactivity after adenoviral‐mediated aquaporin‐1 <scp>cDNA</scp> transfer to human parotid glands

Abstract

The data are the first to describe immune responses after adenoviral vector administration in a human parotid gland. Importantly, we found that modest (2-3 fold) changes in systemic cell-mediated immune reactivity did not preclude positive subject responses to gene transfer. However, changes beyond that level likely impeded the efficacy of gene transfer.