Concepedia

Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence

Sjoerd H. den Uil, Veerle M.H. Coupé, Janneke F. Linnekamp, Evert van den Broek, Jeroen Goos, Pien M. Delis‐van Diemen, Eric J.T. Belt, Nicole C.T. van Grieken, Patricia M. Scott, Louis Vermeulen,

British Journal of Cancer · 2016 · 40 citations · 48 references

DOIFull text

Open access

Abstract

We conclude that KCNQ1 is a promising biomarker for prediction of disease recurrence and may aid stratification of patients with stage II MSS colon cancer for adjuvant chemotherapy.

References

48

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit et al. · International Journal of Cancer · 2014 · 28.8K citations · Full text

, , +17

Comprehensive molecular characterization of human colon and rectal cancer

Nature · 2012 · 8.5K citations · Full text

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The consensus molecular subtypes of colorectal cancer

Justin Guinney, Rodrigo Dienstmann, Xin Wang et al. · Nature Medicine · 2015 · 5K citations · Full text

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Improved Overall Survival With Oxaliplatin, Fluorouracil, and Leucovorin As Adjuvant Treatment in Stage II or III Colon Cancer in the MOSAIC Trial

Thierry André, C. Boni, Matilde Navarro et al. · Journal of Clinical Oncology · 2009 · 2.3K citations

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Levamisole and Fluorouracil for Adjuvant Therapy of Resected Colon Carcinoma

Charles G. Moertel, Thomas R. Fleming, John S. Macdonald et al. · New England Journal of Medicine · 1990 · 2.2K citations · Full text