Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading <i>Akkermansia muciniphila</i> and Several Short-Chain Fatty Acid–Producing Microbiota in the Gut

Abstract

Our results support the hypothesis that metformin shifts gut microbiota composition through the enrichment of mucin-degrading A. muciniphila as well as several SCFA-producing microbiota. Future studies are needed to determine if these shifts mediate metformin's glycemic and anti-inflammatory properties.