Efficient and Eco‐friendly Syntheses of 1,5‐Benzothiazepines and 1,5‐Benzodiazepines Catalyzed by [<i>Hmim</i>][NO₃] under Mild Conditions

Abstract

This article presents a synthetic method and reaction mechanism of the 1,5‐benzothiazepines and 1,5‐benzodiazepines derivatives. In this research, 36 thiazepines and diazepines (mostly new) with a new method have been prepared and their structures have been characterized by spectroscopic methods. Crystal structures of a new thiazepine and diazepine (seven‐membered rings) have also been determined and compared with thiazine (six‐membered ring). In this method, N ‐methylimidazolium nitrate [ Hmim ][NO 3 ] has been used as a catalyst that acts as an environmental friendly system.