Involvement of PINK1/Parkin-mediated mitophagy in AGE-induced cardiomyocyte aging

Autophagy in the Pathogenesis of Disease

Beth Levine, Guido Kroemer · Cell · 2008 · 6.9K citations · Full text

Cell Autophagy, Mitophagy, Autoimmune Disease +10

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Taichi Hara, Kenji Nakamura, Makoto Matsui et al. · Nature · 2006 · 3.8K citations

Neural Cells, Cell Autophagy, Neurodegenerative Diseases +12

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Derek P. Narendra, Seok Min Jin, Atsushi Tanaka et al. · PLoS Biology · 2010 · 2.8K citations · Full text

Pink1 Accumulation, Mitophagy, Activate Parkin +18

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

Noriyuki Matsuda, Shigeto Sato, Kahori Shiba et al. · The Journal of Cell Biology · 2010 · 1.9K citations · Full text

Mitophagy, Cell Death, Molecular Biology +16

Selective Mitochondrial Autophagy, or Mitophagy, as a Targeted Defense Against Oxidative Stress, Mitochondrial Dysfunction, and Aging

John J. Lemasters · Rejuvenation Research · 2005 · 1.3K citations

Mitophagy, Mitochondrial Dysfunction, Genetics +17