Concepedia

Tetracyclic dihydronaphthalene derivatives via gold-catalyzed aminative homodimerization of ortho-alkynylbenzaldehydes

Aaron A. Ruch, Fanji Kong, Vladimir N. Nesterov, LeGrande M. Slaughter

Chemical Communications · 2016 · 16 citations · 37 references

DOI

Concepts

Abstract

Gold(i) catalyzes domino homodimerization of o-alkynylbenzaldehydes via a sequence of 6-endo-dig-cyclization, amine addition, and [4+2] cycloaddition involving two bicyclic intermediates. The resulting products integrate medicinally relevant 1,2-dihydronaphthalene and isochromene moieties into a single amine-substituted tetracyclic framework.

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