Analysis of positions and substituents on genotoxicity of fluoroquinolones with quantitative structure-activity relationship and 3D Pharmacophore model

Beware of q2!

Alexander Golbraikh, Alexander Tropsha · Journal of Molecular Graphics and Modelling · 2002 · 3.6K citations

Engineering, Quantum Computing, Post-quantum Cryptography +4

The Importance of Being Earnest: Validation is the Absolute Essential for Successful Application and Interpretation of QSPR Models

Alexander Tropsha, Paola Gramatica, Vijay K. Gombar · QSAR & Combinatorial Science · 2003 · 2.1K citations

Engineering, Machine Learning, Behavioral Decision Making +23

Antimicrobial Resistance: Pharmacokinetics‐Pharmacodynamics of Antimicrobial Therapy: It’s Not Just for Mice Anymore

Paul G. Ambrose, Sujata M. Bhavnani, Christopher M. Rubino et al. · Clinical Infectious Diseases · 2006 · 688 citations · Full text

Mice Anymore, Antimicrobial Chemotherapy, Antibiotic Resistance +17

Occurrence of antibiotics in eight sewage treatment plants in Beijing, China

Lihong Gao, Yali Shi, Wenhui Li et al. · Chemosphere · 2011 · 384 citations

Engineering, Antibiotics, Environmental Engineering +14

Toxicity of the fluoroquinolone antibiotics enrofloxacin and ciprofloxacin to photoautotrophic aquatic organisms

Ina Ebert, Jean Bachmann, Ute Kühnen et al. · Environmental Toxicology and Chemistry · 2011 · 267 citations

Ecotoxicity, Calculated Ec50s, Cyanobacteria +19