Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP‐1‐derived macrophages

Abstract

Our findings suggest that piperine promotes ChE in THP-1-derived macrophages by upregulation of ABCA1, which might be mediated by inhibition of calpain activity. This novel bioactivity makes the dietary constituent piperine a good candidate to be further explored for therapeutic or preventive applications in the context of atherosclerosis.