ANTIDIABETIC EFFECT OF HOLARRHENA ANTIDYSENTERICA SEEDS ON STREPTOZOTOCIN INDUCED DIABETIC RATS.

Abstract

Summary This study was undertaken to evaluate the antidiabetic effect of Petroleum ether (PEHAD) and aqueous (AEHAD) extracts of Holarrhena antidysenterica seeds in normal (Normoglycemic) and in streptozotocin (STZ) induced diabetic rats. On chronic treatment, both petroleum and aqueous extract has showed significant decrease in blood glucose level (BGL), serum cholesterol, triglyceride levels and at the same time markedly increased liver glycogen, thus proving the potentiating property of Holarrhena antidysenteric as antidiabetic drug.