A Powerful CD8⁺ T‐Cell Stimulating D‐Tetra‐Peptide Hydrogel as a Very Promising Vaccine Adjuvant

Abstract

A novel vaccine adjuvant based on a supramolecular hydrogel of a D-tetra-peptide is reported. Antigens can be easily incorporated into the hydrogel by a vortex or by gently shaking before injection. The vaccines can stimulate strong CD8+ T-cell responses, which significantly inhibits tumor growth. This novel adjuvant is expected to enable a wide range of sub-unit vaccines and help the production of antibodies.