Should Thrombolytic Therapy Be the First-Line Treatment for Acute Ischemic Stroke?

Tissue Plasminogen Activator for Acute Ischemic Stroke

The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group · New England Journal of Medicine · 1995 · 11.7K citations

Medicine, Pharmacology, Pharmacotherapy +17

Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)

Werner Hacke · JAMA · 1995 · 2.9K citations

Medicine, Neurology, Pharmacotherapy +17

Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke

Gregory J. del Zoppo, Klaus Poeck, Michael S. Pessin et al. · Annals of Neurology · 1992 · 1K citations

Medicine, Neurosurgery, Surgery +17

Guidelines for Thrombolytic Therapy for Acute Stroke: A Supplement to the Guidelines for the Management of Patients With Acute Ischemic Stroke

Harold P. Adams, Thomas Brott, Anthony J. Furlan et al. · Circulation · 1996 · 734 citations

Medicine, Neurology, Cerebrovascular Surgery +13

Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke

The Lancet · 1995 · 636 citations

Medicine, Neurology, Pharmacotherapy +13