Subcortical ¹⁸F‐AV‐1451 binding patterns in progressive supranuclear palsy

Abstract

The PSP and PD patients showed distinct subcortical ¹⁸ F-AV-1451 binding patterns reflecting subcortical tau pathology in PSP and reduced nigral neuromelanin in PD. However, there was no correlation with the severity of motor dysfunction, no cortical regions with increased binding in PSP patients, and variable degrees of subcortical binding even in the controls. Therefore, the ¹⁸ F-AV-1451 PET may be less than ideal for assessing tau pathology in PSP. Further studies will be required to validate the clinical correlation and to understand the clinical utility of ¹⁸ F-AV-1451 PET for PSP patients. © 2016 International Parkinson and Movement Disorder Society.