Factors affecting <scp>SPF </scp><i>in vitro</i> measurement and correlation with <i>in vivo</i> results

Abstract

In our investigation, we demonstrated that it is possible for a single laboratory to optimize internal methods and protocols to achieve repeatable and predictive in vitro results, but it is extremely difficult to develop methods reproducible and equally reliable in different laboratories, probably due to "external variables" (e.g. environmental, operator), which are difficult to control.