Cardenolides from Calotropis gigantea as potent inhibitors of hypoxia-inducible factor-1 transcriptional activity

Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth

Huafeng Zhang, David Z. Qian, Yee Sun Tan et al. · Proceedings of the National Academy of Sciences · 2008 · 616 citations · Full text

Medicine, Oncology, Pharmacology +11

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

Carmen Chak‐Lui Wong, Huafeng Zhang, Daniele M. Gilkes et al. · Journal of Molecular Medicine · 2012 · 220 citations · Full text

Medicine, Cancer Biology, Oncology +14

Identification of a Novel Cardenolide (2‘ ‘-Oxovoruscharin) from <i>Calotropis </i><i>p</i><i>rocera</i> and the Hemisynthesis of Novel Derivatives Displaying Potent in Vitro Antitumor Activities and High in Vivo Tolerance:  Structure−Activity Relationship Analyses

Eric Van Quaquebeke, Gentiane Simon, Aurélie André et al. · Journal of Medicinal Chemistry · 2005 · 159 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

A New Cytotoxic Pregnanone from Calotropis gigantea

Zhunian Wang, Maoyuan Wang, Wen‐Li Mei et al. · Molecules · 2008 · 101 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +14

Flavonol glycosides from Calotropis gigantea

Sucharita Sen, Niranjan P. Sahu, Shashi B. Mahato · Phytochemistry · 1992 · 93 citations

Life Sciences, Botany, Plant Sciences +8